Blood levels of some toxic metals in Human Immunodeficiency Virus (HIV) Type 1- infection
Background: The introduction of antiretroviral therapy has reduced the mortality rate and increased the average life-expectancy of HIV-infected population. Infection probably due to the combination of the effects of environmental exposures and chronic inflammation and the role of mpact in infected individuals have been under-reported.
Objective: To compare the plasma levels of cadmium (Cd), lead (Pb), mercury (Hg) and nickel (Ni) in HIV 1 –positive subjects receiving highly active anti-retroviral therapy treatment (HAART) and treatment-naïve subjects.
Methods: The 300 study participants comprised 100 confirmed HIV-1 positive individuals on HAART, 100 HIV-1 positive HAART-naïve and 100 HIV-1 negative controls. Plasma levels of toxic metals were determined using inductively coupled plasma mass spectrometer (Agilent 7500, Norwalk, USA).
Results: Plasma levels of toxic metals were significantly higher among HIV-infected subjects than controls (p <0.001), with only Cadmium concentration being significantly higher (p = 0.05) among the HAART-treated subjects than HAART-naïve subjects.
Conclusion: High toxic metal levels may lead to increased oxidative stress and adverse prognostic outcomes. Periodic evaluation of the blood levels of some toxic metals in HIV-1 infected individual is suggested and preventive strategies against environmental pollution should be adopted.
2. Losina E, Freedberg KA. Life expectancy in HIV. BMJ 2011; 343 .doi:10.1136/bmj.d6015.
3. Harrison KM, Song R, Zhang X. Life expectancy after HIV diagnosis based on national HIV surveillance data from 25 states,United States. J Acquir Immune Defic Syndr 2010; 53: 124-130.
4. Smith C, Sabin CA, Lundgren JD, Thiebaut R. Data Collection on Adverse Events of Anti HIV dSG. Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D Study. AIDS 2010; 24: 1537-1548.
5. Deeks SG, Phillips AN. HIV infection, antiretroviral treatment, ageing and non-AIDS related morbidity. BMJ 2009; 338: a3172.
6. Sackoff JE, Hanna DB, Pfeiffer MR, Torian LV. Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City. Ann Intern Med 2006; 145: 397-406.
7. Phillips AN, NeatonJ, Lundgren JD. The role of HIV in serious diseases other than AIDS. AIDS 2008; 22: 2409-2418.
8. Akinola FF, Akinjinmi AA, Oguntibeju OO. Effect of combined Anti-retroviral Therapy on selected trace elements and CD4+ T-cells count in HIV positive persons in an African setting. AIDS Clinic Res 2012; 3: 10.
9. Tellez-Plaza M, Guallar E, Howard BV, Umans JG, Francesconi KA, Goessler W, et al. Cadmium exposure and incident of cardiovascular disease. Epidemiology 2013; 24: 421-429.
10. Moon SS. Association of lead, mercury and cadmium with diabetes in the Korean population: the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010. Diabet Med 2013; 30(4): e143-138.
11. Rhee SY, Hwang YC, Woo JT, Sinn DH, Chin SO, Chon S, et al. Blood lead is significantly associated with m
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