Socio-demographic and other risk factors associated with HBV potential infectivity among Hepatitis B Surface Antigen Negative blood donors

  • Olusogo Ebenezer Busari Department of Haematology, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria.
  • Omotola Toyin Ojo Department of Haematology and Blood Transfusion, Olabisi Onabanjo University Teaching Hospital, Sagamu, Ogun State, Nigeria
  • Yetunde Adebisi Aken'Ova Department of Haematology University College Hospital, Ibadan, Oyo State, Nigeria
Keywords: Anti-HBc, Blood donors, HBsAg, Hepatitis, Risk factors, Socio-demographics


Background: There have been cases of post-transfusion hepatitis in spite of transfusion of hepatitis B surface antigen negative blood unit.

Objective: To determine the socio-demographic and risk factors associated with positivity of anti-HBc among Hepatitis B surface antigen negative blood donors.

Methods: A cross-sectional study was carried out among 490 HBsAg negative blood donors. The participants were tested for anti-HBc using ELISA kits. A structured questionnaire was used to obtain socio-demographic data and other possible risk factors.

Results: The mean age of the participants was 32.5 ± 9.5 years with male predominance of 462 (94.3%) while 375 (76.5%) were first time donors. Of the 490 HBsAg negative blood donors, 89 (18.2%) were positive for anti-HBc.

The highest prevalence of anti-HBc occurred in the 26-34 years age group. Independent risk factors associated with the presence of anti-HBc included age (p = 0.049), marital status (p = 0.003), dental and surgical procedure (p<0.001), traditional practices such as tattoo, body piercing and scarification (p<0.001) and previous blood transfusion (p = 0.016).

Conclusion: Age, marital status, traditional and cultural practices like scarifications, tattoo and body piercing and history of blood transfusion were risk factors associated with HBV infection despite HBsAg negativity.


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Original Research