Prevalence of microalbuminuria among adults with Type 2 Diabetes mellitus at OOUTH, Sagamu

  • Adebayo Adetola Amballi Department of Chemical PathologyOlabisi Onabanjo UniversitySagamu http://orcid.org/0000-0002-7828-7270
  • Olatunde Odusan Department of Medicine, Olabisi Onabanjo University, Sagamu
  • Omobola Abioye Ogundahunsi Department of Chemical PathologyOlabisi Onabanjo UniversitySagamu
  • Alfred Ademola Jaiyesimi Department of MedicineOlabisi Onabanjo UniversitySagamu
  • Sunday Kolawole Oritogun Department of Community Medicine and Primary CareOlabisi Onabanjo UniversitySagamu
  • Wasiu Eniola Olooto Department of Chemical PathologyOlabisi Onabanjo UniversitySagamu
Keywords: Chronic Kidney Disease, Glycated haemoglobin, Hypertension, Microalbuminuria, Obesity, Diabetes mellitus

Abstract

Background: Diabetes mellitus is a serious global epidemic. The menace of this chronic disease is attributable to its chronic complications which threaten both the world economy and life expectancy, especially in Sub- Saharan Africa. Nephropathy is a complication of Diabetes mellitus and a leading cause of End Stage Renal Disease.

Objectives: To determine the prevalence of microalbuminuria as well as the effects of co-morbidities on the pattern of microalbuminuria among adults with Type 2 Diabetes mellitus.

 Methods: A total of 325 adults with Diabetes mellitus and 100 controls without Diabetes mellitus were studied. The subjects with diabetes were classified into four groups ([i] diabetes only, [ii] diabetes with hypertension, [iii] diabetes with obesity and [iv] diabetes with hypertension and obesity). Urinary protein, microalbuminuria, fasting plasma glucose and Glycated Haemoglobin (HbA1c) were measured using standard methods.

Results: The overall prevalence of microalbuminuria was 35.1% in the diabetic population compared to 8.0% in the control group. The prevalence of microalbuminuria in the various diabetic subgroups were as follows: 30.3% (diabetes only), 43.1% (diabetes with hypertension), 37.0% (diabetes with obesity) and 44.6% (diabetes with hypertension and obesity). The fasting plasma glucose and HbA1c were statistically significantly higher in the diabetic population than the control group. This indicated that there is a poor glycaemic control in the diabetic population and hence a possible cause of diabetic nephropathy.

Conclusion: The risk of diabetic nephropathy was significant in the study population. The presence of one or more co-morbidities and poor glycaemic control increased the occurrence of diabetic nephropathy.

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Published
2018-06-17
Section
Original Research