Serum Ferritin and Blood Pressure modulation in first-time and regular blood donors

  • Oluseye Vincent Osunkalu CMUL, University of Lagos
  • Alani Sulaimon Akanmu college of medicine, university of Lagos, Nigeria
  • Aderonke Shakirat Lawal -Folorunsho college of medicine, university of Lagos, Nigeria
Keywords: Blood pressure, Long term blood donation, Serum ferritin, Voluntary blood donors, Blood pressure, Long term blood donation, Serum ferritin, Voluntary blood donors


Background: The health benefits of blood donation are well known. However, the overall effect of long term regular blood donation on body iron store and blood pressure need to be evaluated among voluntary blood donors.

Objective: To determine the effect of long term, regular blood donation on body iron store and blood pressure among regular voluntary non-remunerated blood donors in Lagos, Nigeria.

Methods: Consenting adult blood donors (n = 320), ranging from the first time to regular blood donors were studied over six months. Supine blood pressure (BP) readings were taken twice at 30 minutes interval with a mercury sphygmomanometer. Venous whole blood was drawn into EDTA anti-coagulated and plain tubes for haematological parameters and serum ferritin estimation using Enzyme-linked Immunosorbent Assay (ELISA) method.

Results: The mean serum ferritin levels declined significantly from 95.5ng/mL among first time donors to 68.9ng/mL among Category III donors (p = 0.035). Male voluntary blood donors had increased risk of low serum ferritin level (OR = 5.02; 95%CI= 1.12-22.51; p = 0.035). Lower values of serum ferritin were recorded more frequently among donors within the 21-30 year age category (OR = 1.54; 95%CI = 1.0-2.71; p= 0.042). Long term regular voluntary blood donation was associated with significant reduction in mean systolic blood pressure (p = 0.01).

Conclusion: Long term blood donation resulted in the reduction of blood pressure. Progressive increase in the duration of donation resulted in reduced iron stores even as haemoglobin concentration levels remained acceptable for blood donation.

Author Biographies

Alani Sulaimon Akanmu, college of medicine, university of Lagos, Nigeria


department of Haematolology and Blood Transfusion, College of Medicine, Idi-Araba, Lagos, Nigeria

Rank: Professor

Aderonke Shakirat Lawal -Folorunsho, college of medicine, university of Lagos, Nigeria

Department of Haematolology and Blood Transfusion, College of Medicine, Idi-Araba, Lagos, Nigeria

rank: postgraduate fellow


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Original Research