Relationship between bone markers and cardiovascular risk factors in healthy Nigerian adults

Keywords: Bone Turnover Marlers, Calcium, Cardiovascular Risk Factors, Osteocalcin, Nigeria

Abstract

Background: Osteoporosis and cardiovascular diseases are global public health concerns. Both diseases have been linked through common risk factors and biological mechanisms.

Objective: To evaluate the association between bone turnover markers (BTM) and some cardiovascular risk factors among healthy Nigerian adults.

Methods: This was a cross-sectional, observational study of 80 healthy participants of less than 50 years of age. Clinical data were obtained through an interviewer-based questionnaire. Fasting blood samples were analysed for Osteocalcin (OC), Total Alkaline phosphatase (ALP), 25-hydroxyvitamin D (25-OHVitD), Calcium (Ca), Fasting Blood Glucose (FBG). Two-hour postprandial blood glucose (2HPP) Calcium-phosphorus product calculated (CAP) and 24-hour urinary calcium excretion (CaE) were determined.

Results: The mean age of the participants was 32.1±5.8 years, mean BMI was 26.3±4.0kg/m2 and the mean waist circumference (WC) was 79.6±16.0cm. OC was directly correlated with ALP (r = 0.4, p = 0.006) but not with CaE (p = 0.8). Serum OC was inversely correlated with age, BMI and WC. ALP was negatively correlated with FBG (r = - 0.3, p = 0.04), 2HPP (r = - 0.65, p = 0.000). Multivariate regression showed that BTMs-OC, ALP and CAE independently predicted BMI, 2HPP, DBP and FBG respectively.

Conclusion: This study showed a relationship between bone markers and selected cardiovascular risk factors in Nigerian adults. Therefore, patients with cardiovascular disease may benefit from bone health screening or vice versa.

Author Biography

OB Familoni

 

 

 

References

Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. Am J Med 1991; 90: 107-110.

http://en.m.wikipedia.org/wiki/cardiovascular_diseases. Accessed February 2019.

Lampropoulos CE, Papaioannou I, D'Cruz DP. Osteoporosis-a risk factor for cardiovascular disease? Nat Rev Rheumatol 2012; 8: 587-598.

Bhupathiraju SN, Lichtenstein AH, Dawson-Hughes B, Hannan MT, Tucker KL. Adherence to the 2006 American Heart Association Diet and Lifestyle Recommendation for Cardiovascular disease reduction is associated with bone health in Older Puerto Ricans. Am J Clin Nutri 2013; 98: 1309-1316.

Florencio-Silvia R, Sasso GR, Sasso-Cerri E, Simoes MJ, Cerri PS. Biology of Bone Tissue: Structure, function and factors that influence bone cells. Bio Res Int 2015; 4: 1-17.

Vishram JK. Prognostic Interaction between cardiovascular risk factors. Dan Med J 2014; 16: E4892.

Guntur AR, Rosen CJ. Bone as an endocrine organ. Endocr Pract 2012; 18: 758-762.

Magni P, Macchi C, Sirtori CR, Corsi-Romanelli MM. Osteocalcin as a potential risk biomarker for cardiovascular and metabolic diseases. Clin Chem Lab Med 2016; 54: 1579-1587.

Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, et al. Endocrine regulation of energy metabolism by skeleton. Cell 2007; 130: 456-469.

Meredith LZ, Thomas LC, Ryan CR. New Insights into the biology of Osteocalcin. Bone 2016; 82: 42-49.

Jung CH, Lee WJ, Hwang JY, Lee MJ, Seol SM, Kim YM, et al. The preventive effect of uncarboxylated osteocalcin against free fatty acid-induced endothelial apoptosis through the activation of phosphatidylinositol 3-kinase /Akt signalling pathway. Metabolism 2013; 62: 1250-1257.

Magni P.Bicuspid aortic valve, atherosclerosis and changes of lipid metabolism: Are there pathological molecular links? J Mol Cell Cardiol 2019: 129: 231-235.

Vasselle C, Maffei S, Iervasi G. Bone remodelling biomarkers: New actors on the Old cardiovascular stage. In Biomarker-Technological, Clinical and Commercial Aspects, KGaA; Wiley-VCH Verlag GmbH& Co: Weinheim, Germany. 2015: 107-146.

Lowe D, John S. Alkaline phosphatase. In: Stat Pearls. Available at http://www.ncbi.nlm.nih.gov/books. Accessed February 2019.

Cheung CL, Tan KC, Lam KS, Cheung BM. The relationship between glucose metabolism, metabolic syndrome and bone-specific Alkaline phosphatase: A structural equation modelling approach. J Clin Endocrinol Metab 2013; 9: 3856-3863.

Pike JW, Christakos S. Biology and mechanisms of action of the vitamin-D hormone. Endocrinol Metab Clin North Am 2017; 46: 815-843.

Rai V, Agrawal DK. Role of Vitamin D in cardiovascular disease. Endocrinol Metab Clin North Am 2017; 46: 1039-1059.

Schnatz PF, Manson JE. Vitamin D and cardiovascular diseases: An appraisal of evidence. Clin Chem 2014; 60: 600-609.

Polgreen LE, Jacobs DR, Nathan BM, Steinberger J, Moran A, Sinaiko AR. Association of osteocalcin with obesity, insulin resistance, and cardiovascular risk factors in young adults. Obesity 2012; 11: 2194-2201.

Satu P, Mervi P, Mervi T, Maila T, Merja K, Outi M, et al. Bone Health and Risk Factors of Cardiovascular Disease- A Cross-Sectional Study in Healthy Young Adults. PLoS One 2014; 9 :e108040.

Bao Y, Zhou M, LuZ, LiH, Wang Y, Sun L, et al. Serum osteocalcin are inversely associated with metabolic syndrome and severity of coronary artery disease in Chinese men. Clin Endocrinol (Oxf) 2011; 75: 196-201.

Vanderschueren D. Gevers G, Raymaekers, Devos P,Dequeker. Sex –and age-related changes in bone and serum Osteocalcin. Calcif Tissue Int 1990; 46: 179-182.

Kord-Varkaneh H, Djafarian K, Khorshidi M, Shab-Bidar S. Association between Osteocalcin and Body Mass Index: A Systematic Review and Meat-Analysis. Endocrine 2017; 58: 24-32.

Manghat P, Souleimanov I, Cheung J, Wierzbicki AS, Harrington DJ, Shearer MJ, et al. Association of bone turnover markers and arterial stiffness in pre-dialysis chronic kidney disease. Bone. 2011; 48: 1127-1132.

Cristina V, Laura S, Pietro DC, Maristella M, RudinaN, Silvia M, et al. Relationship between bone health biomarkers and cardiovascular risk in a General Adult Population. Diseases. 2017; 5: 24.

Bell TD, DemayMB, Burnett-Bowie SA. The biology and pathology of vitamin-D control in bone. J Cell Biochem 2010; 111: 7-13.

Reid IR, Birstow SM, Bollard MJ. Calcium and cardiovascular disease. Endocrinol. Metab (Seoul). 2017; 32: 339-349.

Reid IR, Gamble GD, Bollard MJ. Circulating calcium concentrations, vascular disease and mortality: Serum calcium and cardiovascular risk factors and diseases: a systematic review. J Intern Med 2016; 279: 524-540.

Ale AO, Osalusi BS, Adeyemo OL. Vitamin D Status and bone health in healthy adult Nigerians. Afr J Endocrinol Metab 2019 (In press).

Published
2020-08-22
Section
Original Research