Physical Exercise and Glucose Tolerance in Nigerian University Students

  • EO Taiwo
  • LO Thanni
Keywords: Bicycle Ergometer, Exercise, Glucose tolerance, Oral Glucose Tolerance Test

Abstract

Background: Studying post-prandial fluctuations in blood glucose has high physiological and clinical relevance. Physical exercise is known to influence this fluctuation.

Objectives: To determine the gender difference in glucose tolerance following physical exercise in a population of university students.

Methods: A total of 146 students were randomly selected from the Olabisi Onabanjo University, Sagamu, Ogun State, southwest Nigeria. Following overnight fast, Oral Glucose Tolerance Test (OGTT) was carried out. Pre-exercise, fasting blood glucose (FBG) was measured at 0 mins, and after oral glucose load of 75 grams at 30 minutes intervals for 2 hours. The physical exercise involved cycling using a bicycle ergometer for an hour. Thereafter, OGTT was conducted again 1 hour post-exercise.

Results: The ages of the subjects ranged from 20 years to 49 years. There were 73 (50.0%) females. The mean Body Mass Index (BMI) of 23.5±1.1 kg/m2 for females was comparable to 22.8±0.3 kg/m2 for the males (p = 0.571). Seven (9.6%) females were obese compared to 2 (2.7%) males. The mean post-prandial blood glucose increased from 71.6±1.6 mg/dl to 90.8±1.8 mg/dl after oral glucose load and thereafter to 88.0±4.2 mg/dl at 120 minutes among males. The post-exercise blood glucose patterns included a significant reduction in the mean FBS for males compared to females (64.5±1.9 mg/dl vs. 71.7±1.9 mg/dl; p = 0.001)

Conclusions: Glucose tolerance with exercise is better in females than males. The clinical importance of physical exercise lies in its effect on glucose tolerance.

References

International Diabetes Federation. Diabetes Atlas. 8th Edition. Brussels: International Diabetes Federation; 2017.

Bertram MY, Lim SS, Barendregt JJ, Vos T. Assessing the cost-effectiveness of drug and lifestyle intervention following opportunistic screening for pre-diabetes in primary care. Diabetologia 2010; 53: 875–881. https://doi.org/10.1007/s00125-010-1661-8.

Zeppetzauer M, Drexel H, Vonbank A, Rein P, Aczel S, Saely CH. Eccentric endurance exercise economically improves metabolic and inflammatory risk factors. Eur J Prev Cardiol 2013; 20: 577–584.

Paschalis V, Nikolaidis MG, Theodorou AA, Panayiotou G, Fatouros IG, Koutedakis Y, et al. A weekly bout of eccentric exercise is sufficient to induce health-promoting effects. Med Sci Sports Exerc. 2011; 43: 64–73.

Jensen TE, Richter EA. Regulation of glucose and glycogen metabolism during and after exercise. J Physiol 2012; 590: 1069–1076.

Cook MD, Myers SD, Kelly JS, Willems ME. Acute Post-Exercise Effects of Concentric and Eccentric Exercise on Glucose Tolerance. Int J Sport Nutr Exerc Metab 2015; 25: 14–19.

Church TS, Blair SN, Cocreham S, Johannsen N, Johnson W, Kramer K, et al. Effects of aerobic and resistance training on hemoglobin A1c levels in patients with Type 2 Diabetes: a randomized controlled trial. JAMA 2010; 304: 2253-2262.

Slentz CA, Bateman LA, Willis LH, Shields AT, Tanner CJ, Piner LW, et al. Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab 2011; 301: E1033-1039.

Hales D. An invitation to Health, 2009-2010 Edition. Boston, MA: Wadsworth Cengage Learning; 2009.

Adeleke OR, Ayenigbara GO. Preventing Diabetes Mellitus in Nigeria: Effect of Physical Exercise, Appropriate Diet, and Lifestyle Modification. Int J Diabetes Metabolism 2019; 25: 85-89. https://doi.org/10.1159/000502006.

Prasanna NS, Amutha A, Pramodkumar TA, Anjana RM, Venkatesan U, Priya M, et al. The 1 h post glucose value best predicts future dysglycemia among normal glucose tolerance subjects. J Diabetes Complications 2017; 31: 1592-1596. https://doi.org/10.1016/j.jdiacomp.2017.07.017.

Published
2020-11-25
Section
Original Research