Seroprevalence of Transfusion Transmissible Infections Among Voluntary Blood Donors at an Indian Hospital

Authors

  • M Kundra
  • S Sood
  • SP Gulia
  • N Sharma

DOI:

https://doi.org/10.30442/ahr.0703-10-141

Keywords:

Blood donors, Blood Transfusion, Seroprevalence, Transfusion Transmissible Infections

Abstract

Background: The knowledge of the incidence of blood Transfusion Transmissible Infections (TTIs) such as Hepatitis B, Hepatitis C, Human Immunodeficiency Virus infection, malaria and syphilis is essential for monitoring the safety of blood supply.

Objective: To describe the prevalence of TTIs for monitoring blood supply safety and evaluating the efficacy of screening procedures.

Methods: A five-year retrospective study spanning January 2016 to December 2020 was carried out on voluntary blood donors at blood donation camps organised by Adesh Medical College and Hospital, Kurukshetra, Haryana, India, and from donors at the hospital’s blood bank. The donated blood was tested for Hepatitis-B, Hepatitis-C, Human Immunodeficiency Virus (HIV), malaria and syphilis.

Results: There were a total of 10,468 voluntary blood donors during the period of study. Out of all the donors, 0.4% tested positive for at least one of the TTIs, including 0.06% testing positive for HIV, 0.21% for Hepatitis-B virus (HBV) infection (Hepatitis-B Surface Antigen) and 0.13% for Hepatitis-C virus (HCV) infection (Anti HCV Antibodies). None of the voluntary donors was positive for malaria or syphilis. There were no co-infections.

Conclusions: The prevalence of TTIs among voluntary blood donors was low hence the advocation for blood from this group of donors. Donated blood specimens should be more effectively screened, and blood should be rationally used.

References

Arora D, Arora B, Khetarpal A. Seroprevalence of HIV, HBV, HCV and Syphilis in blood donors in Southern Haryana. Indian J Pathol Microbiol 2010; 53: 308-309. https://doi.org/10.4103/0377-4929.64295

Deshpande RH, Bhosale S, Gadgil PA, Sonawane M. Blood Donor's Status of HIV, HBV, HCV and Syphilis in this region of Marathwada, India. J Krishna Inst Med Sci University 2012; 1: 111-116.

Chandra T, Rizvi SNF, Agarwal D. Decreasing Prevalence of Transfusion transmitted infections in Indian Scenario. Scientific World J 2014; Article ID 173939 http://dx.doi.org/10.1155/2014/173939

Chougale RA, Shinde PJ. Seroprevalence of Transfusion Transmitted Infections among voluntary blood donors at a tertiary care teaching hospital in Kolhapur, India. Int J Recent Trends Sci Technol 2017; 22: 01-06. https://dx.doi.org/10.18535/jmscr/v7i7.07

Leena MS, Shafee M. Trend and prevalence of transfusion transmitted infections among blood donors in rural teaching institute, South India. J Pathol Nepal 2012; 2: 203-206. https://doi.org/10.3126/jpn.v2i3.6022

Sharma DC, Rai S, Bharat S, Iyenger S, Gupta S, Jain B. A 10-year Comparative Study to Assess Trends in Seroprevalence of Transfusion Transmitted Infections among Blood Donors at Gwalior, India. Open J Blood Dis 2014; 4: 24-32. https://doi.org/DOI:10.4236/ojbd.2014.42004

Kaur G, Basu S, Kaur R, Kaur P, Garg S. Patterns of infections among blood donors in a tertiary care centre: A retrospective study. Natl Med J India 2010; 23: 147-149.

Chandra T, Kumar A, Gupta A. Prevalence of transfusion transmitted infections in blood donors: an Indian experience. Trop Doct 2009; 39: 152-154. https://doi.org/10.1258/td.2008.080330

Singh B, Verma M, Kotru M, Verma K, Batra M. Prevalence of HIV and VDRL Seropositivity in blood donors of Delhi. Indian J Med Res 2005; 122: 234-236.

Unnikrishnan B, Rao P, Kumar N, Ganti S, Prasad R, Amarnath A, et al. Profile of blood donors and reasons for deferral in Coastal South India. Australas Med J 2011; 4: 379-385. https://doi.org/10.4066/AMJ.2011.641

Kulkarhni N. Analysis of the seroprevalence of HIV, HBsAg, HCV and Syphilitic infections detected in the pretransfusion blood: A short report. Int J Blood Transfus Immunohematol 2012; 2: 1-3. https://doi.org/:10.5348/ijbti-2012-6-SR-1

Sidhu M, Kotwal U, Kapoor R, Rainia T. Seroprevalence of human immunodeficiency virus, Hepatitis B virus and Hepatitis C virus in blood donors of Jammu Province: A tertiary care centre experience. Asian J Transfus Sci 2013; 7: 162-163. https://doi.org/10.4103/0973-6247.115601

Karmakar PR, Shrivastava P, Ray TG. Seroprevalence of Transfusion Transmissible Infections among blood donors at the blood bank of a medical college of Kolkata. Indian J Public Health 2014; 58: 61-64. https://doi.org/10.4103/0019-557X.128172

Dobariya GH, Raja KA, Unagar CA, Pandya AN, Patel JN, Jarag MA, Wadhwani SJ. Prevalence and trends of transfusion transmitted infections among blood donors of blood bank attached to government hospital of South Gujarat, India. Int J Res Med Sci 2016; 4: 4123-4127. http://dx.doi.org/10.18203/2320-6012.ijrms20162946

Fatima A, Begum F, Kumar KM. Seroprevalence of Transfusion Transmissible Infections among Blood Donors in Nizamabad District of Telangana State - A six-year study. Int Arch IntegMed 2016; 3: 73-78. http://dx.doi.org/10.21088/ijprp.2278.148X.6217.24

Mandal R, Mondal K. Transfusion transmissible infections among blood donors from a sub-Himalayan rural tertiary care centre in Darjeeling, India. J Trad Complem Med 2016; 6: 224-229. https://doi.org/10.1016/j.jtcme.2015.02.003

Arya DR, Mahawar NL, Pachaury R, Bharti A, Sharma L, Kumar H, et al. Seroprevalence of Transfusion Transmissible Infections among blood donors at a tertiary care hospital blood bank in North India. Indian J Health Sci 2016; 9: 77-81. https://doi.org/10.4103/2349-5006.183695

Agrawal P. Jain S, Surana SS, Sujanani S. Prevalence of Transfusion Transmitted Infections among Blood Donors at a tertiary care teaching hospital in Southern Rajasthan. Ann Pathol Lab Med 2017; 4: A-137-A-141. https://doi.org/10.21276/APALM.1095

Chandekar SA, Amonkar GP, Desai HM, Valvi N, Puranik GV. Seroprevalence of Transfusion Transmissible Infections in Healthy blood donors: A 5-year tertiary care hospital experience. J Lab Physicians 2017; 9: 283-287. https://doi.org/10.4103/0974-2727.214246

Arora I, Singh S, Singh S. Seroprevalence and Trends of Transfusion Transmitted Infections in blood donors of rural tertiary care hospital blood bank: A 3-year retrospective study in Chamba (HP). Int J Community Med Public Health 2018; 5. http://dx.doi.org/10.18203/2394-6040.ijcmph20182176

Sundramurthy R, Arunagiri R, Ganesan V, Perumal S, Tiruvannamalai R, Charles J. Seroprevalence of transfusion transmissible infections among blood donors by chemiluminescent assay in a tertiary care centre. J Infect Dev Ctries 2018; 12: 031-036. https://doi.org/10.3855/jidc.9430

Sood S, Malvankar S. Seroprevalence of Hepatitis B Surface Antigen, Antibodies to the Hepatitis C virus, and Human Immunodeficiency Virus in a Hospital-based population in Jaipur, Rajasthan. Indian J Community Med 2010; 35: 165-169.

Giri PA, Deshpande JD, Phalke DB, Karle LB. Seroprevalence of transfusion transmissible infections among voluntary blood donors at a tertiary care teaching hospital in rural area of India. J Family Med Prim Care 2012; 1: 48-51. https://doi.org/10.4103/2249-4863.94452

Patel PJ. Transfusion transmissible infection in blood donors: A 7-year study in Central Gujarat. Med J Dr. D.Y. Patil University 2014; 7: 620-624. https://doi.org/10.4103/0975-2870.140451

Suresh B, Babu KVS, Venkataramana B, Mouli PC. Burden of transfusion transmissible viral infections among blood donors at a tertiary care referral teaching hospital in South India. J Clin Sci Res 2016; 5: 160-163. https://doi.org/10.15380/2277-5706.JCSR.15.023

Lakshmikumar MT, Shruthi B, Gaddi VJ, Hanumantharaya C. Prevalence of Transfusion Transmitted Infections among blood donors: Five years Retrospective Study from Rural Tertiary Care Hospital of South Karnataka. Galore Int J Health Sci Res 2019; 4: 113-115. https://doi.org/10.1016/j.jtcme.2015.02.003

Makroo RN, Walia RS, Chowdhry M, Bhatia A, Hegde V, Rosamma NL. Seroprevalence of anti-HCV antibodies among blood donors of North India. Indian J Med Res 2013; 138: 125-128.

Kumar A, Sharma S, Ingole N, Gangane N. Rising trends of HCV infection over a period of 4 years among blood donors in Central India: A retrospective study. Int J Med Public Health 2013; 3: 240-243. https://doi.org/10.4103/2230-8598.123430

Datta S, Khillan K, Ranjan V, Wattal C. Nucleic acid amplification test: Bridging the gap in blood safety and re-evaluation of blood screening for cryptic transfusion - transmitted infection among Indian donors. Indian J Med Res 2019; 149: 389-395. https://doi.org/10.4103/ijmr.IJMR_1340_17

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Published

2021-09-27

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Original Research