MILLER-FISHER SYNDROME - A CASE REPORT
Miller-Fisher syndrome is a syndrome of ataxia, areflexia and ophthalmoplegia which was first described by Miller Fisher in 1956. The disorder has an immunological basis and has been regarded as a descending form of Guillain – Barré syndrome (GBS). It is a rare clinical condition which may be confused with other common illnesses.
This report describes a nine-year-old boy who presented with a five-day history of diplopia and difficulty in walking following an upper respiratory tract infection. On examination, he had ataxia, ophthalmoplegia and areflexia with cerebrospinal fluid cytoalbuminological dissociation. This case report emphasises the need to have a high index of clinical suspicion in patients with features of cranial mononeuropathy multiplex and hyporeflexia.
Fisher M. An unusual variant of the acute idiopathic polyneuritis (syndrome of ophthalmoplegia, ataxia and areflexia). N Engl J Med 1956: 255: 57- 65.
Berlit P, Rakicky J. The Miller Fisher syndrome: a review of the literature. J Clin Neuropthalmol 1992: 12: 57-63.
Garret P. A child with Miller Fisher syndrome. J Paediatr Child Health 2002; 38: 414- 416.
Gülçin A, Muzaffer P, Ayşe T, Gül S, Sarenur G, Hasan T. Miller Fisher syndrome, a case with pattern of pure sensory polyneuropathy concomitant with anti- GQIb antibody. Turkish J Paediatr 2007; 49: 109-112.
Govoni V, Granieri E, Tola MR, Casetta I, Ruppi P, Vaghi L. The frequency of clinical variants of Guillain-Barré syndrome in Ferrara, Italy. J Neurol. 1999; 246: 1010- 1014.
Jones H. Guillain – Barre syndrome. Perspective with infants and children. Semin Paediatr Neurol 2000; 7: 91-102.
Willison H. Ganglioside autoantibodies. In: Peter J, Shoefield Y (eds). Autobodies. Elsevier Science. Amsterdam. 1996: 277 – 284.
Editorial: Influenza Vaccination and the Guillain – Barre syndrome. N Eng J Med 1998; 339: 1845-1846.
Amason BG, Solive B. Acute inflammatory demyelinating polyradiculoneuropathy. In: Dyck PJ, Thomas PK, Griffin JW, Low PA, Podusla JF (eds). Peripheral neuropathy. 3rd Ed. Philadelphia, PA: Saunders. 1993: 1437- 1497.
Paparounas K. Anti- GQIbganglioside antibody in peripheral nervous system disorders: pathophysiologic role and clinical relevance. Arch Neurol 2004: 61: 1013-1016.
Chiba A, Kusunoki S , Shimizu T, Kanazawa I. Serum IgG antibody to gangliosideGQIb is a possible marker of Miller Fisher syndrome. Ann Neurol 1992; 31: 677-679.
Willison HJ. Fine specificity of anti GQIb antibodies and clinical features. J Neurol Sci 2001; 185: 1-2.
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