Effect of exercise on basal insulin levels in normoglycaemic offspring of patients with Type 2 Diabetes mellitus

  • EO Taiwo
  • OA Sofola
  • AA Fasanmade
  • G Onyemelukwe
Keywords: Diabetes mellitus, Graded exercise, Insulin levels, Offspring


Background: Low basal insulin level is a risk factor for Type 2 Diabetes mellitus (T2DM) as a result of altered insulin sensitivity pattern. However, it is uncertain if exercise may influence the occurrence of T2DM in the offspring of diabetic parents.
Objective: To assess the effect of exercise on basal insulin levels in the offspring of T2DM parents compared with the offspring of non-diabetic parents.
Design: The participants were assigned into four groups using a convenience sampling method; 27 Normal-weight Offspring of Non-Diabetic Parents (NONDP), 21 Normal-weight Offspring of Diabetic Parents (NODP), 26 Overweight Offspring of Non-Diabetic Parents (OONDP) and 21 Overweight Offspring of Diabetic Parents (OODP). Each participant followed a protocol of graded exercise using ''tummy trimmer'' everyday spending 30-45 minutes daily for 24 weeks. Blood samples were obtained after overnight fasting for determination of insulin level using standard methods (immunoassay technique) at baseline, six weeks, 12 weeks, 18 weeks and 24 weeks respectively.
Results: There were 23/42 males (54.8%) in the study groups and 34/51 females (64.2%) in the control groups. Thirty-one (58.7%) in the control group and 24 (57.1%) in the study group were aged 21-30 years. An increase in insulin levels was recorded at 12 weeks in all groups except in NONDP where the insulin levels decreased. The insulin level change was highest in the NODP (2.25ng/ml) group.
Conclusions: Graded exercise improved insulin levels in all test groups. The clinical importance of graded exercise in the prevention of diabetes mellitus among the offspring of diabetic parents may be promising.



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Original Research