Adiposity, Proinflammatory Indices, Apolipoproteins and Antioxidants’ Activities in Relation to the Severity of Hypertension
DOI:
https://doi.org/10.30442/ahr.1101-05-269Keywords:
Anthropometry, Antioxidants, Dyslipidaemia, Hypertension, Serum lipid profile, Proinflammatory markersAbstract
Background: Hypertension is an important risk for several chronic illnesses, notably heart failure, stroke, chronic renal disease and others. In these chronic disease conditions, promising biochemical parameters could be of immense diagnostic value.
Objectives: To investigate adiposity indices, lipid Profile, apolipoproteins, proinflammatory markers and antioxidant status among subgroups of hypertensive patients.
Methods: The study involved 150 participants aged 18-65 years, consisting of 50 normotensives as control subjects and 100 hypertensive individuals as the test group. The blood pressures (BP) of the participants were measured. Their body mass index and waist-to-hip ratio were calculated. Serum lipid profile, serum levels of apolipoprotein-A, apolipoprotein-B, glutathione, catalase, superoxide dismutase, high sensitivity C-reactive protein, tumour necrosis factor-α and interleukin-6 were also measured.
Results: There was a significant increase (p<0.001) in adiposity measures, Apo-B (p<0.001), IL-6 (p<0.001), hs-CRP levels (p<0.001), and dyslipidaemia among hypertensive patients. Apo A (p<0.001), glutathione (p<0.001) and SOD (p<0.001) showed significantly lower levels in the test group. A strong positive correlation was observed between BP and anthropometric profiles (BMI, WC; r = 0.754; p =0.001), serum lipids (TC, triglycerides; r = 0.417; p = 0.01), Apo-B (r = 0.726; p = 0.01) and proinflammatory markers (TNF-α, IL-6; r = 0.845; p = 0.01). Also, a strong negative but significant correlation existed between BP and antioxidants (GSH, SOD; r = -0.632; p = 0.01), and Apo-A (r = -0.838; p = 0.01).
Conclusion: The study showed that adiposity indices, serum lipid parameters, serum apolipoproteins, proinflammatory markers and antioxidants could serve as diagnostic tools for complications of hypertension.
References
1. Jeffery M. Hypertension Guidelines: Revisiting the JNC 7 Recommendations. J Lancaster Gen Hosp 2008;3:91-97.
2. Mills KT, Stefanescu A, He J. The global epidemiology of hypertension. Nat Rev Nephrol 2020;16:223-237. https://doi.org/10.1038/s41581-019-0244-2.
3. Nomin B, Azahar NM, Kitaoka K, Kobayashi Y, Yano Y. African control of hypertension through innovative epidemiology and a vibrant ecosystem (ACHIEVE): Novel strategies for accelerating hypertension control in Africa. J Hum Hypertens 2025;39:83-85. https://doi.org/10.1038/s41371-023-00845-7.
4. Ogungbe O, Abasilim C, Huffman MD, Ojji D. Hypertension Treatment in Nigeria Program Team. Improving hypertension control in Nigeria: early policy implications from the Hypertension Treatment in Nigeria program. Glob Health Res Policy 2024;9:1-9. https://doi.org/10.1186/s41256-024-00368-9.
5. Hata M, Mujadzic H, Skeete J, DiPette DJ. Historical, present, and emerging biomarkers in hypertension: a narrative review. J Lab Precis Med 2022;7:1-12. https://doi.org/10.21037/jlpm-22-7407.
6. Amar J, Shere A, Eletta O, Goyal H. Circulating blood biomarkers in essential hypertension: A literature review. J Lab Precis Med 2017;2:1-12. https://doi.org/10.21037/jlpm.2017.12.06.
7. Johannesen CDL, Langsted A, Mortensen MB, Nordestgaard BG. Association between low-density lipoprotein and all-cause and cause-specific mortality in Denmark: Prospective cohort study. BMJ 2020;371:m4266. https://doi.org/10.1136/bmj.m4266.
8. Nayor M, Vasan RS. Cholesterol treatment guidelines: a comparison with international guidelines. Circulation 2016;133:1795-1806. https://doi.org/10.1161/CIRCULATIONAHA.116.021407.
9. Mach F, Baigent C, Catapano AL, Koskinas KC, Casula M, Badimon L, et al. ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J 2020;41:111-188. https://doi.org/10.1093/eurheartj/ehz455.
10. Koh TJ, Dipietro LA. Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med 2011;13:e23. https://doi.org/10.1017/S1462399411001943.
11. Choi B, Lee C, Yu JW. Distinctive role of inflammation in tissue repair and regeneration. Arch Pharm Res 2023;46:78-89. https://doi.org/10.1007/s12272-022-01356-7.
12. Yamane Y. Mathematical formulae for sample size determination. 1967.
13. American Heart Association. Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension 2018;71:e13-e115. doi:10.1161/HYP.0000000000000065.
14. Christian O, Yaa O, Emmanuel A, Enoch OA, Emmanuel T, Evans AA, et al. Association of waist circumference and waist-to-height ratio with cardiometabolic risk factors among Type II diabetics in a Ghanaian population. J Diabetes Res 2018;14:11. https://doi.org/10.1155/2018/1381396.
15. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502. https://doi.org/10.1093/clinchem/18.6.499.
16. Schettler G, Nussel E. Colorimetric determination of cholesterol. Arch Med Soz Med Prav Med 1975;10:55.
17. Pisa PT, Macclesfield LK, Kagura J, Ramsay M, Crowther NJ, Norris SA, et al. Different adiposity indices and their association with blood pressure and hypertension in middle-aged urban black South African men and women: findings from the AWI-GEN South African Soweto Site. BMC Public Health 2018;18:524. https://doi.org/10.1186/s12889-018-5440-4.
18. Sierra-Johnson J, Fisher RM, Romero-Corral A, Somers VK, Lopez-Jimenez F, Wallidius G, et al. Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality. Eur Heart J 2009;30:710-717. https://doi.org/10.1093/eurheartj/ehp026.
19. Rutkowski M, Grzegorczyk K. Modifications of spectrophotometric methods for antioxidative vitamins determination convenient in analytic practice. Acta Sci Pol Technol Aliment 2007;6:17-28.
20. Rutkowski M, Grzegorczyk K, Paradowski MT. Colorimetric method of blood plasma total vitamin E determination – the own modification of Tsen method. Diagn Lab. 2005;41:375.
21. Rutkowski M, Grzegorczyk K, Gendek E, Kedziora J. Laboratory convenient modification of Bessey method for vitamin A determination in blood plasma. J Physiol Pharmacol 2006;57:221.
22. Góth L. A simple method for determination of serum catalase activity and revision of reference range. Clin Chim Acta 1991;196:143-151. https://doi.org/10.1016/0009-8981(91)90067-M.
23. Sinha KA. Colorimetric assay of catalase. Anal Biochem 1972;47:389-394. https://doi.org/10.1016/0003-2697(72)90132-7.
24. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988;34:497-500. https://doi.org/10.1093/clinchem/34.3.497.
25. Kazemi-Saleh D, Koosha P, Sadeghi M, Sarrafzadegan N, karbasi-Afshar R, Boshtam M, et al. Predictive role of adiponectin and high-sensitivity C-reactive protein for cardiovascular event prediction in an Iranian cohort study: The Isfahan Cohort Study. ARYA Atheroscler. 2016;12:132-137.
26. Afshari JT, Ghomian N, Shameli A, [(add 3 more authors, before et al.] et al. Determination of interleukin-6 and tumour necrosis factor-alpha concentrations in Iranian-Khorasanian patients with preeclampsia. BMC Pregnancy Childbirth. 2005;5:14. https://doi.org/10.1186/1471-2393-5-14.
27. Abbot RD, Wilson PW, Karvel WB, Castel WP. High density lipoprotein cholesterol, total cholesterol severing myocardial infarction. Atherosclerosis 1988;8:207-211.
28. Alladi S, Shanmugasundaram KR. Induction of hypercholesterolemia by supplementing soy protein with acetate generating amino-acids. Nutr Rep Int 1989;40:893-899.
29. Lindsey ML, Pollow DP Jr, Uhlorn JA, Sylvester MA, Romero-Aleshire MJ, Uhrlaub JL, et al. Menopause and FOXP3+ Treg cell depletion eliminate female protection against T cell-mediated angiotensin II hypertension. Am J Physiol Heart Circ Physiol 2019;317:H415–H423. https://doi.org/10.1152/ajpheart.00792.2018.
30. Shin KA, Kim YJ. The usefulness of surrogate markers of body fat distribution for predicting metabolic syndrome in middle-aged and older Korean populations. Diabetes Metab Syndr Obes 2019;12:2251–2259. https://doi.org/10.2147/DMSO.S217628.
31. Pisa PT, Micklesfield LK, Kagura J, Ramsay M, Crowther NJ, Norris SA. Different adiposity indices and their association with blood pressure and hypertension in middle-aged urban black South African men and women: findings from the AWI-GEN South African Soweto Site. BMC Public Health 2018;18:524. https://doi.org/10.1186/s12889-018-5443-4.
32. Landi F, Calvani R, Picca A, Tosato M, Martone AM, Ortolani E, et al. Body Mass Index is strongly associated with hypertension: Results from the Longevity Check-up 7+ Study. Nutrients. 2018;10:1976. https://doi.org/10.3390/nu10121976.
33. Ginsberg HN, Zhang YL, Hernandez-Ono A. Metabolic syndrome: Focus on dyslipidemia. Obesity (Silver Spring). 2006;14:41S-49S. https://doi.org/10.1038/oby.2006.282.
34. Morita SY. Metabolism and modification of apolipoprotein B-containing lipoproteins involved in dyslipidemia and atherosclerosis. Biol Pharm Bull 2016;39:1-24. https://doi.org/10.1248/bpb.b15-00716.
35. Touyz RM, Rios FJ, Alves-Lopes R, Neves KB, Camargo LL, Montezano AC. Oxidative stress: A unifying paradigm in hypertension. Can J Cardiol 2020;36:659-670. https://doi.org/10.1016/j.cjca.2020.02.081.
36. Verma MK, Jaiswal A, Sharma P, Kumar P, Singh AN. Oxidative stress and biomarker of TNF-alpha, MDA and FRAP in hypertension. J Med Life 2019;12:253-259. https://doi.org/10.25122/jml-2019-0024.
37. Puszkarska A, Niklas A, Głuszek J, Lipski D, Niklas K. The concentration of tumour necrosis factor in the blood serum and in the urine and selected early organ damages in patients with primary systemic arterial hypertension. Medicine (Balt). 2019;98:e15773. https://doi.org/10.1097/MD.0000000000015773.
38. Elsayed AM, Ibrahim WM, Grawesh SA, Elbadawy AM. Study of the relation between IL-6, insulin resistance, and blood pressure in essential hypertensive patients. Egypt J Hosp Med 2022;88:2549-2553. https://doi.org/10.21608/ejhm.2022.191588.
39. Xiao L, Harrison DG. Inflammation in hypertension. Can J Cardiol 2020;36:635-647. https://doi.org/10.1016/j.cjca.2020.01.013
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